Sensitivity and Specificity of Cardiac Troponin I and duration of Cardiopulmonary Bypasses in Predicting Arrhythmia
Published: 2021-09-28
Page: 98-105
Issue: 2021 - Volume 3 [Issue 1]
Abdelmonem Helal
Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia and Department of Pediatrics Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Masroor H. Sharfi *
Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia.
Mohamed H. Mashaly
Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia and Department of Pediatrics Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Osama Abdelaziz
Department of Pediatrics Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Abdul Hadi Al-Ghamdi
Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia.
Abdullah A. Al-Shehri
Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia.
*Author to whom correspondence should be addressed.
Abstract
Aim: The sensitivity and specificity of cardiac troponin I (cTnI) and cardiopulmonary bypasses (CPB) in predicting arrhythmia remain unclear. This study aimed to investigate the association of CPB duration and cTnI with the type of arrhythmias.
Study Design: It is a retrospective observational study.
Place and Duration of Study: The study took place in New Children Hospital in Cairo, Egypt between May 2018-December, 2019.
Methods: The study included a total of thirty-three patients who underwent open-heart surgery. Patients between the age of 2 months and 12 years of both gender with the diagnosis of tetralogy of Fallot, ventricular septal defect, and atrioventricular defect were included in the study. Patients with preoperative high-level of cTnI and a history of major intraoperative events were excluded from the study. The accuracy was calculated using sensitivity and specificity. The area under the ROC curve (95% CI) and p-value were calculated.
Results: Out of thirty-three patients undergoing open-heart surgery, 58.1% were male and were 12 months or more (71%). A statistically significant correlation between arrhythmia, cTnI, and CPB was observed (p < 0.05). cTnI predicted high-level sensitivity for arrhythmias, hospital stay, and ICU stay, while low specificity was reported for cTnI as compared to CPB.
Conclusion: The higher level of cTnI was correlated with the underlying burden of arrhythmias. A novel high-sensitivity cTnI assay can protectively recognize patients at low risk of arrhythmias.
Keywords: Arrhythmia, cardiac troponin I, cardiopulmonary bypass, sensitivity, specificity