Asian Journal of Research in Cardiovascular Diseases

Coronary Heart Disease Secondary to Familial Hypercholesterolemia: A Fast Killer

Hanane Mechal *

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

Samia Ejjebli

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

Meryem Haboub

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

Salim Arous

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

Mohamed El Ghali Benouna

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

Abdenacer Drighil

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

Leila Azzouzi

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

Rachida Habbal

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

*Author to whom correspondence should be addressed.

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Abstract

Familial hypercholesterolemia is an autosomal disorder characterized by increased levels of total cholesterol and low density lipoprotein cholesterol. The FH clinical phenotype has been shown to be associated with increased coronary heart disease and premature death. We report two cases of homozygote familial hypercholesterolemia (IIa) in brothers, presenting coronary artery disease at an early age, with a very disturbed lipid profile, rapidly progressive and diffuse coronary lesions, with the occurrence of early death in both brothers before the age of 30.

Keywords: Familial hypercholesterolemia, homozygous familial hypercholesterolemia, dyslipidemia, coronary heart disease, xanthoma

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