An Evaluation of Anti-Hyperlipidemic Activity of Rubus idaeus on High Fat Induced Rat Model with Safety Profile Analysis
Published: 2023-12-13
Page: 163-170
Issue: 2023 - Volume 5 [Issue 1]
F. M. Sharifuzzaman Shohan
Department of Pharmacy, Primeasia University, Bangladesh.
Juliana Aditi Baroi
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Puja Bhowmik
Department of Pharmacy, University of Science & Technology Chittagong, Bangladesh.
Md. Abdullah Hil Baky Rupak
Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.
Md. Rahmat Ullah
Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.
Md. Abu Bakar Siddiq
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi Dhaka-1205, Bangladesh.
Tasin Islam Pranto
Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi Dhaka-1205, Bangladesh.
Mohammad Shahjalalur Rahman Siam
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
Rafat Tashin *
Department of Pharmacy, Primeasia University, Bangladesh.
*Author to whom correspondence should be addressed.
Abstract
One abundant source of medications is medicinal plants. Therefore, medicinal plants may be thought of as a broad class of medications against many illnesses. These days, hyperlipidemia is a prevalent condition that is causing a great deal of misery for its victims. There are a lot of synthetic medications available to treat this illness, but the most of them have a lot of adverse effects. Thus, a substitute in this case could be therapeutic plants. Rubus idaeus is one of the plant specimens that have been utilised as an alternative medication to treat hyperlipidemia. It can be used as a substitute source of hyperlipidemia treatment. In this study, rats with hyperlipidemia from a high-fat diet were treated with Rubus idaeus extract. Rats in the red Rubus idaeus extract administration groups demonstrated a significant (p<0.05) reduction in body weight and cholesterol levels after an 8-week intragastric Rubus idaeus extract gavage compared to the group that did not receive Rubus idaeus extract treatment. The total cholesterol and triglyceride levels in the hyperlipidemia mice were significantly (p<0.05) reduced by the Rubus idaeus extract therapy. In you study we aimed to assess the therapeuteic consequences of our plant and as per our findings this plant possess compounds that may impart anti-hyperlipidemic activity evnethoug the concentration of therapeutic compound is not sufficient. More vigorous is needed to identify and isolate precise compound that can be a potential candidate of hyperlipidemia treatment.
Keywords: Rubus idaeus, hyperlipidemia, medicinal, high fat diet, cholesterol