Asian Journal of Research in Cardiovascular Diseases

An Evaluation of Anti-Hyperlipidemic Activity of Rubus idaeus on High Fat Induced Rat Model with Safety Profile Analysis

F. M. Sharifuzzaman Shohan

Department of Pharmacy, Primeasia University, Bangladesh.

Juliana Aditi Baroi

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Puja Bhowmik

Department of Pharmacy, University of Science & Technology Chittagong, Bangladesh.

Md. Abdullah Hil Baky Rupak

Department of Pharmaceutical Sciences, North South University, Plot # 15, Block # B, Bashundhara R/A, Dhaka, 1229, Bangladesh.

Md. Rahmat Ullah

Department of Pharmacy, University of Asia Pacific, Farmgate, Dhaka, Bangladesh.

Md. Abu Bakar Siddiq

Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi Dhaka-1205, Bangladesh.

Tasin Islam Pranto

Department of Pharmacy, State University of Bangladesh, 77 Satmasjid Road, Dhanmondi Dhaka-1205, Bangladesh.

Mohammad Shahjalalur Rahman Siam

Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.

Rafat Tashin *

Department of Pharmacy, Primeasia University, Bangladesh.

*Author to whom correspondence should be addressed.

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Abstract

One abundant source of medications is medicinal plants. Therefore, medicinal plants may be thought of as a broad class of medications against many illnesses. These days, hyperlipidemia is a prevalent condition that is causing a great deal of misery for its victims. There are a lot of synthetic medications available to treat this illness, but the most of them have a lot of adverse effects. Thus, a substitute in this case could be therapeutic plants. Rubus idaeus is one of the plant specimens that have been utilised as an alternative medication to treat hyperlipidemia. It can be used as a substitute source of hyperlipidemia treatment. In this study, rats with hyperlipidemia from a high-fat diet were treated with Rubus idaeus extract. Rats in the red Rubus idaeus extract administration groups demonstrated a significant (p<0.05) reduction in body weight and cholesterol levels after an 8-week intragastric Rubus idaeus extract gavage compared to the group that did not receive Rubus idaeus extract treatment. The total cholesterol and triglyceride levels in the hyperlipidemia mice were significantly (p<0.05) reduced by the Rubus idaeus extract therapy. In you study we aimed to assess the therapeuteic consequences of our plant and as per our findings this plant possess compounds that may impart anti-hyperlipidemic activity evnethoug the concentration of therapeutic compound is not sufficient. More vigorous is needed to identify and isolate precise compound  that can be a potential candidate of hyperlipidemia treatment.

Keywords: Rubus idaeus, hyperlipidemia, medicinal, high fat diet, cholesterol

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