Asian Journal of Research in Cardiovascular Diseases <p style="text-align: justify;"><strong>Asian Journal of Research in Cardiovascular Diseases</strong>&nbsp;aims to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJRCD/general-guideline-for-authors">Click here for Types of paper</a>) in all areas of&nbsp;‘Cardiovascular Diseases’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> <p style="text-align: justify;">&nbsp;</p> en-US (Asian Journal of Research in Cardiovascular Diseases) (Asian Journal of Research in Cardiovascular Diseases) Sat, 19 Jun 2021 07:22:36 +0000 OJS 60 Congenitally Corrected Transposition of Great Arteries Associated with Interrupted Aortic Arch Type A, Complex and Rare Anatomy Detected by Echocardiography: A Case Report <p>We report an extremely rare case of congenitally corrected transposition of great arteries (CCTGA) (Pic. 1) &nbsp;associated with interrupted aortic arch (IAA) type A (Pic. 2) and a ventricular septal defect (VSD), in a preterm infant born at 36 weeks of gestation with a birth weight of 2.5 kg. This baby was diagnosed in utero with a large VSD and severe coarctation of the aorta. A comprehensive echocardiographic examination confirmed the diagnosis and revealed that the congenitally corrected transposition of great arteries was associated with Interrupted aortic arch type A. A review of the literature revealed only one similar case, reported earlier by Cottrell, et al. [1]. In their case, the initial diagnosis was confirmed angiographically as 2D and color Doppler echocardiography were not available in their center. The clarity of echocardiographic images obtained in our institution enabled us to make this diagnosis without needing additional imaging modalities. The infant was managed successfully as he underwent an aortic arch repair using an end-to-end anastomosis and a pulmonary artery (PA) band placement as a palliation towards second stage repair.</p> Abdulhadi Alghamdi, Masroor Sharfi, Amin M. Arfi, Mohammad Shehata, Antonio R Cerrudo, Jameel Al Ata ##submission.copyrightStatement## Sat, 19 Jun 2021 00:00:00 +0000 Homozygous PKP2 Deletion Associated with Left Ventricular Noncompaction and Arrhythmia <p>Left ventricular noncompaction cardiomyopathy (LVNC) is a genetic cardiomyopathy, characterized by prominent left ventricular trabeculations and deep intertrabecular recesses. Relatively few responsible genes have been identified. Plakophilin-2 (PKP2) is a component of the desmosome complex and is known for its role in cell-to-cell adhesion. Heterozygous variants of the PKP2 gene deletion that encoding the desmosomal protein plakophilin-2, are associated with arrhythmogenic right ventricular cardiomyopathy (ARVC). The homozygous variant of the PKP2 deletion has been described only once in a case associated with LVNC.</p> <p>Here, we are reporting a total homozygous PKP2 deletion, after molecular genetic analysis of whole-exome sequencing (WES), which was identified in a 4- month boy with severe (LVNC). He presented with intractable congestive heart failure (CHF) and arrhythmia of Wolf – Parkinson - White syndrome (WPW) and ventricular tachycardia (VT). Our results support not only the association of PKP2 with ventricular noncompaction cardiomyopathy, but also WPW and VT.</p> Abdalrahman Ali Ahmed Alhassan, Tajudeen Bushari, Sami M. Al-Ahmari, Motea E. Elhoury ##submission.copyrightStatement## Fri, 03 Sep 2021 00:00:00 +0000 Comparative Safety and Efficacy of Left Main vs. Non-left Main PCI Optimized using Rotational Atherectomy and Drug-Eluting Stent Implantation in Patients with Chronic Kidney Disease <p><strong>Background:</strong> Left main coronary artery disease (LMCAD) is associated with poor cardiovascular outcomes, especially in patients with coexisting chronic kidney disease (CKD). Percutaneous coronary intervention (PCI) using rotational atherectomy (RA) and newer generation drug-eluting stents (DES) has been shown to improve outcomes in CKD patients with complex anatomical lesions. In this study, we assessed and compared the outcomes with this treatment strategy in CKD patients with LMCAD versus non-LMCAD.</p> <p><strong>Methodology: </strong>This was a single-center, retrospective study. From January 2015 to September 2017, all CKD patients with calcified CAD who underwent RA followed by second-generation DES implantation at our center were included and divided into subgroups based on left main disease involvement. The primary endpoint was major adverse cardiac and cerebrovascular events ([MACE] composite of all-cause mortality, myocardial infarction (MI), and stroke). Key secondary endpoints include incidence of cardiac arrest, cardiogenic shock, need for emergency coronary bypass surgery and stent deployment failure.</p> <p><strong>Results:</strong> A total of 203 patients were included in the analysis. The majority of the patients in both groups had mild-to–moderate CKD (45.2% vs. 33.8% mild; moderate: 487.9% vs. 60%; severe: 6.1% vs 6.8%; for LMCAD and non-LMCAD patients, respectively). Prognostically worse and procedurally more difficult lesions such as ostial lesions and calcified bifurcations were significantly higher in the LMCAD group vs. the non-LMCAD group (37% vs. 14.6%; p=0.0005 and 68.5% vs 45.4%; p=0.0025, respectively). There were no significant differences in the primary endpoint event rate, between the LMCAD and non-LMACAD groups (12 [9%] vs. 10 [13.7%]; p=0.4548). Myocardial infarction significantly varied between the LMCAD and non-LMACD groups (0% vs. 3 [4.11%]; p=0.0453). Cardiac arrest, arrhythmia, cardiogenic shock, need for emergency coronary bypass surgery, and failure to deploy stent also did not vary between the LMCAD and non-LMCAD groups.</p> <p><strong>Conclusion:</strong> Percutaneous coronary intervention using RA followed by second-generation DES results in improved clinical outcomes in patients with LMCAD disease. Further, the severity of CKD does not affect cardiovascular outcomes in patients with LMCAD and non-LMCAD patients.</p> Fazila-Tun-Nesa Malik, Md. Kalimuddin, Nazir Ahmed, Mohammad Badiuzzaman, Abdul Kayum Khan, Ashok Dutta, Tawfiq Shahriar Huq, Dhiman Banik, Mir Nesaruddin Ahmed, Md. Habibur Rahman, Md. Abu Tareq Iqbal ##submission.copyrightStatement## Sat, 19 Jun 2021 07:23:49 +0000 Difference in BMI and Body Fat Measurement between Bangladeshi Men and Women Living in Hamtramck, Michigan: A Cross-Sectional Study <p><strong>Background. </strong>There is evidence that points towards an increased preponderance of CVD among Bangladeshi American adults. Yet, most health data on Bangladeshi Americans were derived from New York studies or were clustered with other Asian subgroups.</p> <p><strong>Aim. </strong>To determine whether there is a difference in body mass index (BMI) and body fat measurement between Bangladeshi men and women living in Hamtramck, Michigan.&nbsp;&nbsp;</p> <p><strong>Method.&nbsp; </strong>A cross-sectional study design. A convenient sample of adult Bangladeshis who attended two scheduled community events in Hamtramck, Michigan.&nbsp;&nbsp;</p> <p><strong>Results. The m</strong>ean age of the participants was 48.6 (SD-13.9) years of age and 59% were men. A statistically significant difference was found in the BMI between Bangladeshi men and women, with women having a higher BMI (t(40) = -2.87, p=0.006).&nbsp; Both men and women have high body fat measurements, but not statistically different.&nbsp;</p> <p><strong>Conclusion: </strong>Bangladeshi women living in Hamtramck, Michigan may be at an increased risk of developing CVD. &nbsp;</p> Meriam Caboral-Stevens, Tsu-Yin Wu ##submission.copyrightStatement## Tue, 10 Aug 2021 00:00:00 +0000 Cardiovascular Risk Factor Profile among Public Servants in a Developing Country: A Look at the Prevalence of Metabolic Syndrome in a Nigerian University Community <p><strong>Background:</strong> Cardiovascular diseases are surreptitiously increasing in developing countries unlike the declining trend in the developed world. Screening for risk factors is vital for early detection and control of these diseases. The University community; being compositely mixed, forms a handy surrogate for such latitudinal study in the general population of any community.</p> <p><strong>Objective: </strong>To determine the cardiovascular risk factor profile among workers in a federal government University in South East, Nigeria.</p> <p><strong>Materials and Methods: </strong>Blood pressure, obesity indices, fasting blood lipid and glucose were done, relevant questionnaire administered and the data analyzed using SPSS 16.0 statistical software.</p> <p><strong>Results: </strong>Among the participants, 29.7% had metabolic syndrome (33.1% females; 23.9% males) and for the individual risk factors: Abdominal Obesity; 42.7%, Hyperglycemia; 20.3%, Hypertension; 43.2%, High triglycerides; 11.5%, “Low” High Density Lipoprotein (HDL); 66.0%, Tobacco smoking; 2.1%. Mean age and mean blood pressure were significantly higher in males while total cholesterol was significantly higher in the females.</p> <p>Among the sexes and the workers, the higher prevalence of the parameters occurred thus: Females (abdominal obesity, hyperglycemia, and low HDL); Males (age, hypertension (HBP) and hypertriglyceridemia (high TG); senior staff (abdominal obesity, hypertension and low high density lipoprotein (HDL)); Junior staff (hyperglycemia and high Tg). High BP, high triglycerides and low HDL occurred mostly in the age group 40- 49 years.</p> <p>Metabolic syndrome increased with BMI and age.In all groupings of age and BP, both increased in females but not in males.</p> <p><strong>Conclusion: </strong>Metabolic risk indices are prevalent among University workers in South East Nigeria.</p> E. I. Onwubuya, G. I. Ahaneku, R. A. Analike, J. S. Agbo, J. E. Ahaneku, A. A. Oladejo ##submission.copyrightStatement## Mon, 13 Sep 2021 00:00:00 +0000